Help with Organic Chemistry Lab Sn2!!!?
In lab we have to come up with our own procedure for the synthesis of 30 mmol of benzyl t-butyl ether. The starting products are benzyl bromide and potassium tert- butoxide. I am lost and do not know where to start. I did a internet search and came across williamson ether synthesis but that is not helping me know what techniques to use. Can someone help me out????
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the t-butoxide undergoes nucleophilic attacks on the PhCH2-Br, it will replace the Br and give you PhCH2-OC(CH3)3 and KBr. I’d use t-butanol as the solvent. Williamson ether synthesis is just the name for this type of reactions (alkoxide replacing a halide to form ether).
The procedure listed in wiki is pretty good.
A typical Williamson reaction is conducted at 50–100°C and is complete in 1–8 hours. Often the complete disappearance of the starting material is difficult to achieve, and side reactions are common. Yields of 50–95% are generally achieved in laboratory syntheses, while near-quantitative conversion can be achieved in industrial procedures.